Hyperthermia therapy employs artificial heat to treat malignant tumors. Hyperthermia uses a variety of physical energy to produce thermal effects in the body tissue. Hyperthermia elevates the temperature of tumor tissues to a certain degree and makes it maintained for a certain period of time to kill cancer cells and prevent normal cells from damage. Compared with other conventional therapy, hyperthermia has its special advantages and has become one of the novel comprehensive medical treatments for cancer therapy. This paper briefly reviews the action mechanism on hyperthermia against tumors and its clinical application in the treatment of gastrointestinal cancer.