Chinese Journal of Clinical Pharmacology and Therapeutics 2001;6(1):25-27

Protective effect of extracts of ginkgo biloba leaves on apoptosis in neuronal cells

Yan ZHANG ; Liang MING ; Jingpei LI ; Weiping LI ; Ming FANG

Keywords

ginkgo biloba leaves; neuronal cell; apoptosis of cell

Country

China

Language

Chinese

Abstract

AimTo study the effect of extracts of ginkgo biloba leaves(GbE) on apoptosis in neuronal cells. Methods Primary cerebral cultures from rat fetus were used to observe the activity of neuronal cells and to determine the release of LDH and DNA gel electrophoresis. Results Gb E enhanced the activity of neuronal cells, decresed the release of LDH,and relieved the structural changes of nucleus and DNA fragmentation. Conclusion GbE can inhibit apoptosis in neuronal cells.