Chinese Journal of Pharmacology and Toxicology 2001;15(2):159-160
Effects of genistein on the proliferation of cardiac fibroblasts
Zhan GAO ; Miaozhang ZHU ; Shisheng ZHOU ; Shunyan LU ; Haitao GUO ; Feng GAO ; Xinliang MA
Country
China
Language
Chinese
Abstract
To study the effect of genistein on the proliferation of cardiac fibroblasts(CF), CFs were cultured from neonatal rat hearts, DNA synthesis of the cells was determined by incorporation of ［3H］TdR into DNA, the cell cycle was measured by flow cytometric analysis. Genistein(0.5－50 μmol*L-1) attenuated 2.5% fetal calf serum-induced proliferation of CF in concentration-dependent manner. Genistein(50 μmol*L-1) arrested CF cell progression at G2/M phase. The results suggest that genistein be a potential substance for treatment of cardiac fibrosis.
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