Journal of China Medical University 2001;30(2):130-132
Pulmonary Diffusing Capacity and BALF Lymphocyte Phenotype in Sarcoidosis
Xiaolin HE ; Zhi LIU ; Lixia HUANG ; Zhenhua LI ; Runjiang YU
Country
China
Language
Chinese
Abstract
Objective: Our aim was to study whether the cellular bronchoalveolar lavage fluid (BALF) profile was associated with the parameters of pulmonary function tests. Methods:Lung function tests and BAL were carried out in 18 untreated, non-smoking patients suffering from sarcoidosis and 18 normal subjects. Results:(1)Lung function tests were normal at rest in patients with sarcoidosis(P>0.05), the single breath carbon monoxide diffusing capacity decreased (P<0.05),and the small airway function decreased too (P<0.05).(2)The percentage of lymphocytes in BALF of sarcoidosis increased comparing with the normal subjects(P<0.01),and the ratio of CD+4 to CD+8 in BALF increased significantly in sarcoidosis(P <0.05), furthermore, the increase of both the percentage of lymphocytes and the ratio of CD+4 to CD+8 in BALF of sarcoidosis were well nagatively correlated with the decrease of the percentage of DLCO (r=-0.67, P<0.01 and r=-0.55, P<0.05, respectively), the decrease of mid-expiratory flow at 50% of vital capacity (FEF50%) was well correlated with the increase of the percentage of lymphocytes in BALF of sarcoidosis (r=-0.54, P<0.05). Conclusion:Pulmonary diffusing capacity(DLCO) was significently correlated with BALF lymphocyte phenotype,so was small airway function,and can act as the marker of activity of sarcoidosis.
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