Objective:To explore the correlation between personality and mental symptoms in neurosis. Methods: Eighty Patients with neurotic disorder were assessed with the Symptom Check List 90(SCL-90) and Eysenck Personality Questionnaire (EPQ). Results: By stepwise regression analysis, the N score of EPQ was positively correlated with the mean score and factor scores on SCL-90, and their standard regression coefficients were 0.277～0.508. The P score of EPQ was positively correlated with the mean score and the scores of depression, hostility, paranoid idea on SCL-90, and their standard regression coefficients were 0.245～0.362. The E score of EPQ was negatively correlated with the scores of interpersonal sensitivity , depression on SCL-90 and their standard regression coefficients were-0.209 and -0.229. Conclusion: Personality played significant role in neurotic disorders.