Four kinds of indexes were selected to build up the routine immunization quality evaluating system. The indexes were the estimated immunization coverage rate, timely reporting rate of routine immunization report forms, incidence level of diseases related to EPI, and the external factors influencing routine immunization. By using deducing mark method, we evaluated the synthetic routine immunization quality on city and county level in Hubei Province. This evaluating index system and method have the characteristics of easy to perform, credibility, reasonableness and can be applied widely.