Aim To explore the clinical significance of the vWF in the patients with essential hypertension(EH). Methods vWF were measured with enzyme linked immunoabsorbent assay(ELISA) in 103 EH patients and 30 normal controls. The vWF values were compared by age ,gender,and stages of hypertension. Results There were markedly rise in EH patients than that in the normal controls. The vWF was increased with the age and stage of hypertension. The highest vWF was found in male over seventy years. Conclusion vWF may serve as an indicator of injury of endothelium. A positive correlation between endothelium lesion and age was found.