Chinese Journal of Hypertension 2001;9(2):152-153

Effect of Cilazapril on Reactivity of Blood Vessels in Diabetic Rats

Xuan WANG ; Junqian LI ; Jie CHANG ; Dehong CAI ; Pingsheng WU

Country

China

Language

Chinese

Abstract

Objective To investigate the effect of cilazapril on reactivit y of blood vessels in diabetic rats. 　Methods The mesenteric vessels of streptozotocin induced diabetic rats wer e perfused with Kreb-Ringer's solution in vitro,the mesenteric vessels reactivi ty of diabetic rats was measured by physiological recorder. 　Results The responsive continual time to norepinephrine was delay ed signific antly(9.4±3.1 vs 5.2±2.1,P<0.01) and the highest perfusion pressu re decrease significantly in diabetic rats(5.12±0.87 vs 7.81±0.92 kPa, P<0.01); When taken cilazapril showed no difference in these indexes in diabetic animal s.