Chinese Journal of Biochemical Pharmaceutics 2001;22(3):119-120
Preparation and preliminary pharmacodynamic study of rectal suppository of low molecular weight heparin
Guangxi ZHAI ; Hengchang ZANG ; Yuanjun ZHONG
Country
China
Language
Chinese
Abstract
Purpose The aim is to investigate the rectal suppository of low molecular weight heparin（LMWH）.Methods The suppository was prepared by way of heating and fusion，the drug release property was studied with the release test in vitro and the absorption of LMWH into blood was tested by the changes of rabbits blood coagulation time. Results The drug release property in vitro followed Fick′s diffusion equation and LMWH could enter the blood through rectal medication. Conclusion The absorption from the rectum was another route of LMWH into the blood.
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