High dose chemotherapy(HDC) with stem cell transplantion(SCT) has been used widely to treat non-Hodgkin's lymphoma(HHL).Its curative effect has been confirmed by many trials.But controversy still exists,such as application of HDC for various NHL subtypes,the optimum opportunity and method for transplantation.HDC has become standard therapy for recuring cases which are sensitive to chemotherapy and was a suitable consolidation therapy after remission for high-risk cases.Allogenic bone marrow marrow transplantation,only used for some special cases,need further study.