Chinese Journal of Hypertension 2004;12(2):120-122

The Effect of Hypertriglyceridemia on Vascular Endothelial Function

Yun HUANG ; Guizhu DAI ; Zongchen FENG ; Chengfa LU ; Bei CHENG ; Qiufen WANG ; Fuding NIE ; Jingdong LI

Keywords

hypertriglyceridemia; endothelium; vasodilatation

Country

China

Language

Chinese

Abstract

Objective To investigate the effect of hypert riglyceridemia on vascular endothelial function. Methods With high-resolution ultrasound, flow and nitroglycerin-induced dilatation of the brachial artery were determined in thirty hypertriglyceridemic patients and thirty healthy subjects as controls. Serum lipid and plasma endothelin (ET) were determined. Results In patients with hypertriglyceridemia,flow-induced vasodilatation was much reduced compared with that in the control subjects[(2.7±2.0)% vs (15.0±8.0)%, P<0.001］.However, vasodilatation in response to nitroglycerin were similar in both groups［(15.0±5.0)% vs (16.8±9.0)%, P>0.05].Plasma ET level in the hypertriglyceridemic group was significantly higher than that in the control group［(106.22±19.16) μg/L vs (72.37±14.06) μg/L, P<0.001].ConclusionEndothelium-dependent vasodilatation was impaired in patients with hypertriglyceridemia.