International Journal of Pediatrics 2011;38(2):139-141

doi:10.3760/cma.j.issn.1673-4408.2011.02.014

The biological characteristics of p300/CBP-associated factor and relationship with disease

Jingyun XIE

Keywords

p300/CBP-associated factor; Histone acetyltransferases; Histone modification

Country

China

Language

Chinese

Abstract

p300/CBP-associated factor (PCAF)is an important histone acetyltransferase in eukaryotic cells. PCAF can acetylizes histone and non-histone. PCAF participates in various biological processes of cells and in the interaction between virus and cells. The imbalance of PCAF would lead to abnormal development of various organs, and related to the development of some tumors.