Chinese Journal of Veterinary Science 2009;29(7):898-900

Toxic effect of oral ricin on the mouse intestinal tract and immune organs

Linna LIU ; Hongwei GAO ; Ying DONG ; Zhiping XIA ; Xiaohuan ZOU ; Jiping LI ; Wensen LIU ; Jiayu WAN

Keywords

ricin; intestinal tract damage; immune organs damage

Country

China

Language

Chinese

Abstract

The experiment aimed to study the toxic effect of oral ricin on gastrointestinal tract and immune organs of mice with the dose of 1/5 LD50.In early days of intoxication,there was an obviously decrease in daffy weight and relative weight of thymus and spleen,fllowing the excretion of toxin,they had a trend of recovering to the normal state.Also,results of pathological section,scanning electron microscope and transmission electron microscope showed that ricin would induce a series of pathological reaction in intestines,meanwhile,the splenocytes displayed significant symptom of apoptosis and necrosis.