Journal of Medical Research 2009;38(8):64-65

Assessment of Biliary Excretion of Ceftriaxone Sodium in Humans

Jinglei ZHENG ; Zaiguo WANG ; Lijian LIANG ; Dong CHEN ; Zhiqiang LIN ; Runpei HE

Keywords

Ceftriaxone; Bile; Concentration; Biliary infection; HPLC

Country

China

Language

Chinese

Abstract

Objective To study biliary excretion of ceftriaxone sodium in humans. Methods Twelve biliary calculi patients were infused with a single dose of 2.0g ceftriaxone half an hour before operation and the common bile duct bile and gallbladder bile samples were coUected in the operations. The bile drug concentrations were assayed by HPLC. Results The results of clinical study on the bile drug showed that the concentrations (C) of ceftriaxone in common bile duct and gallbladder were (264.43±166.46) μg/ml and (85.39 ±48.16) μg/ml, respectively. Conclusion Ceftriaxone reaches high concentrations in humans' bile, and it could be chosen as a good antibiotics for the treament of biliary infection.