Chinese Journal of Infection and Chemotherapy 2009;09(4):264-266

Clinical evaluation of linezolid in 15 cases of severe lung infections caused by methicillin-resistant Staphylococcus aureus

Tao XU ; Li YU ; Junhui YANG ; Ding LONG ; Yuanchao ZHANG ; Feng GENG

Keywords

linezolid; methicillin-resistant Staphylococcus aureus; inflammation; lactic acid; inflammatory cytokine

Country

China

Language

Chinese

Abstract

Objective To evaluate the efficacy and safety of linezolid in the treatment of severe lung infections caused by methicillin-resistant Staphylococcus aureus (MRSA).Methods Fifteen patients admitted to ICU due to severe lung infection caused by MRSA received linezolid treatment. WBC, lactic acid (LAC), IL-1β, IL-6, and TNF-α levels were measured before and after treatment. Results Clinical efficacy rate was 73.3%. The level of WBC, LAC and inflammatory cytokines decreased significantly after linezolid treatment (P<0.01).Conclusions Linezolid shows good efficacy in the treatment of severe lung infections caused by MRSA.