Chinese Journal of Pharmacology and Toxicology 2009;23(6):485-489

doi:10.3867/j.issn.1000-3002.2009.06.011

Research advances of phosphokinases for α-synuclein

Yuanyuan ZENG ; Zhongqin LIANG

Keywords

α-synuclein; phosphokinase; protein kinase; Parkinson disease

Country

China

Language

Chinese

Abstract

Abnormal aggregation of α-synuclein(α-Syn) is thought to be a key event in the pathogenesis of Parkinson disease (PD). In recent years, it was shown that above 90% of α-Syn deposited in Lewy bodies in brain tissues from patients with PD is phosphorylated, which suggested that α-Syn phosphorylation be connected with the occurrence of PD. Several kinds of phosphokinases can make α-Syn phosphorylated, however the precise roles of these phosphokinases in PD are less clear.