Chinese Journal of Nervous and Mental Diseases 2010;36(3):145-148

The study on the correlation of C1773T polymorphism of LDL receptor gene (LDLR) with cerebral hemorrhage and its impact on the levels of serum lipids in Chinese

Yi ZENG ; Le ZHANG ; Mingming MA ; Qidong YANG ; Zhongyang HU ; Baoqiong LIU ; Jian XIA ; Yunhai LIU ; Hongwei XU ; Zhiping HU ; Hongxing WANG

Keywords

LDLR; Gene polymorphism; Cerebral hemorrhage; Serum lipid levels

Country

China

Language

Chinese

Abstract

Objective To investigate the relationship between C1773T polymorphism of LDL receptor gene (LDLR) and cerebral hemorrhage and the impact of C1773T polymorphism of LDLR on the levels of serum lipids in Chinese Han in Changsha, Hunan province. Methods Two hundred seventy-three cerebral hemorrhage patients and 140 normal controls were recruited in the present study. The C1773T polymorphism of LDLR was analyzed by SNaPshot and direct DNA sequencing. The triglyceride (TG), total cholesterol (TC), high density lipoprotein-cholesterol (HDL-C) and low density lipoprotein-cholesterol (LDL-C) levels were examined using oxidase method. Results The CC, CT and TT genotype frequencies of LDLR polymorphism were 0.703/0.278/0.019、0.707/0.250/0.043 and the allele C and T frequencies of LDLR polymorphism in the cerebral hemorrhage group and the control group were 0.842/0.158,0.832/0.168 respectively. The differences in genotype and allele frequencies of LDLR polymorphism were no significant between cerebral hemorrhage group and the control group (P>0.05). There were no significant differences in the levels of lipids among the CC, CT and TT genotype in either cerebral hemorrhage group or the control group (P＞0.05). Conclusions The LDLR-C1773T polymorphism may not be associated with cerebral hemorrhage nor be related to hyperlipemia in Chinese Han in Changsha.