Chinese Pharmacological Bulletin 2010;26(4):428-431

The relationship between glyoxalaseⅠand diabetic complications

Zhi LI ; Shijun YAN ; Sitong WANG ; Jun SHENG ; Wensheng ZHANG

Keywords

glyoxalaseⅠ; methylglyoxal; α-oxoaldehydes; AGEs; diabetic complications; regulatory net

Country

China

Language

Chinese

Abstract

GlyoxalaseⅠthat presents in all human tissues detoxifies α-oxoaldehydes and prevents the formation of advanced glycation end products(AGEs).AGEs and their main precursor namely methylglyoxal(MG)produce cytotoxicity and have extensive relationship with diabetic complications.Therefore,to elevate glyoxalaseⅠactivity may be a new path to release such complications.