Virologica Sinica 2010;25(6):381-389

doi:10.1007/s12250-010-3158-5

Isolation and Complete Nucleotide Sequence of the Measles Virus IMB-1 Strain in China

Shaohui MA ; Lichun WANG ; Jiansheng LIU ; Haijing SHI ; Longding LIU ; Qihan LI

Keywords

Complete nucleotide sequence; Genotype H1; Measles virus (MV)

Country

China

Language

Chinese

Abstract

The complete nucleotide sequence of the measles virus strain IMB-1, which was isolated in China, was determined. As in other measles viruses, its genome is 15,894 nucleotides in length and encodes six proteins. The full-length nucleotide sequence of the IMB-1 isolate differed from vaccine strains (including wild-type Edmonston strain) by 4% -5% at the nucleotide sequence level. This isolate has amino acid variations over the full genome, including in the hemagglutinin and fusion genes. This report is the first to describe the full-length genome of a genotype H 1 strain and provide an overview of the diversity of genetic characteristics of a circulating measles virus.