Chinese Journal of Endocrinology and Metabolism 2009;25(4):384-385

doi:10.3760/cma.j.issn.1000-6699.2009.04.007

Effects of pioglitazone on leptin-induced proliferating cell nuclear antigen and leptin receptor expression of vascular smooth muscle cells

Fang WANG ; Xianghua MA ; Jie SHEN ; Yaqin DING ; Xiaoqing YUAN

Keywords

Pioglitazone; Vascular smooth muscle cells; Leptin; Leptin receptor; Proliferating cell nuclear antigen

Country

China

Language

Chinese

Abstract

leptin-induced VSMCs proliferation as well as expression of PCNA and OB-R at both mRNA and protein levels. The maximum effect was at 100 μmol/L(P<0.01).