Korean Journal of Ophthalmology  2009;23(1):46-48

doi:10.3341/kjo.2009.23.1.46

Topical and Oral Voriconazole in the Treatment of Fungal Keratitis.

Sang Joon LEE 1 ; Jung Joo LEE ; Shin Dong KIM

Affiliations

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Keywords

Fungus; Keratitis; Voriconazole

Country

Republic of Korea

Language

English

Abstract

We describe two patients with fungal keratitis refractory to standard antifungal therapy whose conditions were managed with voriconazole. The first case is a patient with endophthalmitis and corneal ulcer due to Candida parapsilosis after receiving a corneal transplant. The patient was treated with amphotericin but showed no signs of improvement. Topical voriconazole, oral voriconazole, and intravitreal voriconazole yielded signs of improvement. The second case is a 63-year-old male who underwent a month of empiric treatment with 0.2% topical amphotericin for fungal keratitis but showed no signs of improvement. Treatment was then provided with 1% voriconazole. Both cases showed effective treatment with voriconazole. Voriconazole may be considered as a new method to treat fungal keratitis refractory to standard antifungal therapy.