Chinese Journal of Rheumatology 2009;13(11):745-748

doi:10.3760/cma.j.issn.1007-7480.2009.11.005

The expression of adiponectin and its receptors in the inflammatory joint of rheumatoid arthritis patients

Fang WANG ; Wenfeng TAN ; Miaojia ZHANG ; Dunming GUO ; Xiaohua LIU ; Youxuan SHEN ; Yao KE ; Shaoheng HE

Keywords

Arthritis rheumatoid; Adiponectin; Adiponectin receptor

Country

China

Language

Chinese

Abstract

Objective To study the expression of Adiponectin (AD) and its receptors Adiponectin receptor 1 (Adipo R1) and Adipo R2 in the synovial fluids and the synovium of rheumatoid arthritis (RA). Methods ELISA was used to determine the levels of AD in 23 RA and 23 osteoarthritis (OA) patients. Real-time PCR and Western blot techniques were employed to study the expression of AD, AdipoR1 and AdipoR2 in the synovium of 10 RA and OA patients. Results It was observed that approximately twice more adiponeetin in the synovial fluids of patients with RA than with OA. Adiponectin and AdipoR1, but not AdipoR2 mRNA, were significantly expressed in synovium of RA patients in comparison with OA. Adiponectin and AdipoR1 protein were wuch more expressed in synovium from RA than those from OA. Conclusion High expression of Adiponectin and AdipoRl is likely to contribute to the formation of inflammatory joints in RA.