Journal of International Oncology 2009;36(11):812-814
doi:10.3760/cma.j.jssn.1673-422X.2009.11.004
Research progression of microenviroment hypoxia influencing DNA damage-repair in tumour cells
Liumei TONG ; Libo FENG ; Xueguan LU
Keywords
Cell hypoxia; DNA mismatch repair; Neoplasms
Country
China
Language
Chinese
Abstract
Microenviroment hypoxia is one of the common phenomenon in cancer,studies have indiacat-ed that hypoxia induces genetic instability via activating many DNA danlage-repair signal pathways,which asso-ciates with tumor invasion and resistance and chemi-radiotherapy resistivity.Here,we overview three main DNA damage-repair pathways:mismatch repair,homologous recombination and non-homologous end joining,and how hypoxia influences their mechanisms.
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