Journal of International Oncology 2009;36(11):833-836

doi:10.3760/cma.j.issn.1673-422X.2009.11.011

Relation between inhibitor of apoptosis protein Apollon and tumor

Yuanyuan LIU

Keywords

Apollon; Neoplasms; inhibitor of apoptosis proteins

Country

China

Language

Chinese

Abstract

Apollon is a member of inhibitor of apoptosis proteins. It can inhibit apoptosis through inter-action with Smac, HtrA2 and caspase. Apollon is highly expressed in a variety of tumors, such as leukemia, breast cancer, brain cancer, carcinoma of mouth and carcinoma of stomach. Apollon may relate with genesis and prognosis of tumor . It also may lead to drug resistance of certain tumors.