International Journal of Surgery 2009;36(12):849-852

doi:10.3760/cma.j.issn.1673-4203.2009.12.022

Effect of interleukin-22 on cell signaling pathways

Xuanhao LI ; Lindong DU

Keywords

interleukin-22; signaling pathways; cell proliferation; cell apoptosis

Country

China

Language

Chinese

Abstract

Interleukin-22 (IL-22) is a new kind of eytokine discovered in 2000. The major sources of IL-22 are activated T1 -cells and NK-cells. Tissue cells at outer body barriers, i.e. of the skin, kidney, the di-gestive and respiratory systems all highly express IL-22R or respond to IL-22. IL-22 functions by promoting the anti-microbial defense, inducing phase reactants, protecting against damage and enhancing natural immu-nity. Furthermore, IL-22 mediates the proliferation, differentiation and apoptesis in cancer cells, that gives us a new idea about tumor therapy.