Chinese Journal of Urology 2009;30(12):816-819

doi:10.3760/cma.j.issn.1000-6702.2009.12.010

Relationship between delayed graft function and glutathione S-transferase polymorphisms

Ziqiang XU ; Jinjun WANG ; Xiaojie NI ; Bicheng CHEN ; Yirong YANG ; Shaoling ZHENG ; Jianjian ZHENG ; Yan CHEN

Keywords

Kidney transplantation; Delayed graft function; Glutathione S-transferase

Country

China

Language

Chinese

Abstract

Objective To explore the factors related to the delayed graft function (DGF). Methods Clinical data of 150 recipients were collected and performed by Cox proportional hazards regression analysis . In addition, the glutathione S-transferase (GST) gene polymorphism of 172 donors and 157 healthy persons was analyzed by multiple PCR and SSP-PCR. Results DGF was observed in 24 patients among 150 recipients. Pretranplantation dialysis mode, PR A levels and recipient gender were uncorrelated with the incidence of DGF(P>0. 05). Urinary volume of the second 24 hours after transplantation was an independent predictor of DGF(RR=1. 002, P = 0. 001). The frequency of donor's null GSTM1 in DGF group was significantly higher than that in non-DGF group(P<0. 05). Conclusions Urinary volume of the second 24 hours after transplantation could be a predictor for DGF. The null GSTM1 in donor might be one of the factors related to the EGF.