Objective To discuss the nursing and experience of patients with AIDS complicated with penicillium marneffei infection.Methods Medicine treatment,medication nursing and psychological nursing were given to 66 patients with AIDS complicated with penicillium marneffei infection through clinical diagnosis,and then the alleviation of clinical symptoms were observed.Results 8 patients abandoned treatment after symptoms improved,13 patients died of multiple organ failure because of their critical condition at admission and complication of drug-resistance bacteria infection.Conclusions Medicine nursing and psychological nursing have pivotal significance for patients with AIDS complicated with penicillium marneffei infection.