International Journal of Cerebrovascular Diseases 2009;17(6):459-462

doi:10.3760/cma.j.issn.1673-4165.2009.06.011

Lipoprotein-associated phospholipase A2 and carotid atherosclerosis

Shujuan DAI ; Qinglong AI

Keywords

phospholipase A2; carotid disease; atherosclerosis

Country

China

Language

Chinese

Abstract

Lipoprotein-associated phospholipase A2(Lp-PLA2) is a novel biomarker for cardiovascular disease. Its expression in symptomatic carotid plaques is higher than that in asymptomatic ones, and its product lysophosphatidylcholine is associated with tissue oxidative stress and inflammation. In addition, Lp-PLA2 plays a more unique role in the unstable difference of carotid atherosclerotic plaques.