Chinese Journal of Obstetrics and Gynecology 2009;44(12):898-902

doi:10.3760/cma.j.issn.0529-567x.2009.12.005

Prevalence of human papillomavirus infection in women in Tibet Autonomous Region of China

Qiong JIN ; Keng SHEN ; Hui LI ; Xianrong ZHOU ; Huifang HUANG ; Jinhua LENG ; Wenhua ZHANG ; Xiaoming GONG ; Xuemei CHENG ; Lang SUO ; Yanchun ZHU ; Jinghe LANG ; Chongmei LU ; Ping WANG ; Wenxin MO

Keywords

Papillomavirus infections; Papiilomaviridae; DNA; viral; Risk factors; Cervix

Country

China

Language

Chinese

Abstract

Objective To determine the prevalence of cervical type-specific human papillomavirus (HPV)infection as well as risk factors associated in Tibet Autonomous Region of China.Methods A cluster sampling study was performed in Lasa,Rikaze and Naqu of Tibet.An epidemiological questionnaire was applied and 3036 cervical specimens were obtained for liquid-based cytology and HPV DNA detection.Statistical analysis included Wald Chi-square and stepwise logistic regression model.Results The overall HPV prevalence of involved 3036 women was 9.19%(279/3036),of which 7.05%(214/3036)of the women were infected by high-risk types (including 14 sorts of types) and 2.14%(65/3036)by low-risk types(including 6 sorts of types).There were no significant differences of HPV prevalence between age groups(P=0.936),race(P=0.718)and areas(P=0.746),respectively.Twenty-one types of HPV were detected,of which HPV16(1.52%) was the most common type,followed by HPV33(1.42%).HPV58(1.22%),HPV52(1.15%),and HPV31(1.05%).HPV type distribution was varied by age.Of the 279 HPV infected women.14.3%(40/279)exhibited multiple HPV infections.Independent risk factors for HPV infection were smoking(P=0.027),number of sex partners(P=0.198)and early age of first intercourse(P=0.237).Conclusion The overall prevalence of HPV infection in Tibet Autonomous Region is lower than that in China or abroad,in which the most common genotype is HPV16 and the independent risk factors for HPV infection included early age of first intercourse,smoking,and number of Bex partners.