Tuberculosis is the leading cause of death due to infection from a single microbial agent. With indepth study of the pathogenesis of tuberculosis,it was found that solute carrier family 11 member I gene SLC11A1) was ignificantly associated with susceptibility to tuberculosis. SLC11A1 is located in phagocytic lysosome membrane,influencing the occurrence and development of tuberculosis by changing the intracellular environment. In this paper, the mechanism of SLC11A1 gene and its relationwith susceptibility to tuberculosis are reviewed.