Chinese Pediatric Emergency Medicine 2010;17(5):454-456

doi:10.3760/cma.j.issn.1673-4912.2010.05.031

Early biomarkers for acute kidney injury

Ling HOU

Keywords

Acute kidney injury; Acute renal failure; Biomarker; IL-18; Kidney injury molecule-1; Liver-type fatty acid binding protein; Nephrotoxicity; Neutrophil gelatinase-associated lipocalin

Country

China

Language

Chinese

Abstract

Acute kidney injury (AKI) represents a common and devastating problem in clinical medicine. The lack of early biomarkers for AKI has led to a delay in initiating potentially effective therapies.Identification of novel biomarkers for AKI has progressed to the clinical phase of the biomarker discovery process. The most promising AKI biomarkers include neutrophil gelatinase-associated lipocalin, IL-18, kidney injury molecule-1 and liver-type fatty acid binding protein. In this article, we review the study of neutrophil gelatinase-associated lipocalin,IL-18, kidney injury molecule-1 and liver-type fatty acid binding protein in recent years,in order to provide the theory basis for the clinical application of the early biomarkers for AKI.