Chinese Journal of General Practitioners 2010;09(10):718-720

doi:10.3760/cma.j.issn.1671-7368.2010.10.021

Differentiation of prostate cancer from benign prostatic hyperplasia (BPH) in the transitional zone by magnetic resonance spectroscopic imaging

Saying LI ; Min CHEN ; Rui WANG ; Wenchao WANG ; Weifeng ZHAO ; Cheng ZHOU

Keywords

Prostatic neoplasms; Magnetic resonance spectroscopy

Country

China

Language

Chinese

Abstract

Twenty patients with prostate cancer and 20 patients with benign prostate hyperplasia (BPH) in the transitional zone underwent magnetic resonance imaging (MRI) /magnetic resonance spectroscopic imaging ( MRSI ) examinations. The choline + creatine/citrate (CC/Ci) ratio and the choline/creatine (Cho/Cr) ratio were evaluated in each voxel with cancer or BPH confirmed by pathological results.Discriminant analysis was used to determine the power of the two ratios in differentiation between cancer and BPH. The CC/Ci ratio and Cho/Cr ratio for cancer voxels were significantly higher than those in the voxels with BPH in the transitional zone (CC/Ci: 2.26 ± 1.35 vs. 0.81 ±0.22, t =5.17, P ＜0. 01, Cho/Cr:4. 12 ± 1.65 vs. 1.25 ±0. 35, P＜0. 01 ). As for the discriminant function with the CC/Cr ratio and the Cho/Cr ratio, the specificity, sensitivity, and accuracy were 99%, 86%, 93% respectively for the differentiation between cancer and BPH.