International Journal of Cerebrovascular Diseases 2010;18(8):637-640

doi:10.3760/cma.j.issn.1673-4165.2010.08.013

The roles of netrin-1 and its receptors in brain ischemia

Qiong GONG ; Jian YU

Keywords

Netrin-1; Netrin receptors; Nerve growth factors; Brain ischemia; Apoptosis

Country

China

Language

Chinese

Abstract

The netrin family represented by netrin-1 is currently one of the most concerned axon guidance factors. Netrin-1 plays guidance roles for axon growth and cell migration by the dual mechanisms of attracting/excluding during the embryonic development. At the same time, netrin-1 also widely expresses in the adult nervous system and involves in the reconstruction of the structure and function after the achft nervous system injury. This article reviews the roles of netrin-1 in ischemic brain injury.