Journal of International Oncology 2010;37(9):676-679

doi:10.3760/cma.j.issn.1673-422X.2010.09.011

Aberrant methylation of tumor suppressor genes in salivary adenoid cystic carcinoma

Chuanming ZHENG

Keywords

Methylation; Tumor suppressor genes; Carcinoma,adenoid cystic; Salivary glands

Country

China

Language

Chinese

Abstract

Methylation of tumor suppressor gene(TSG), currently a hot field in cancer research, is involved in many biological processes including cell cycle regulation, cell signal transduction, DNA apoptosis,tumor invasion and metastasis. The level of TSG methylation is significantly associated with the development of salivary adenoid cystic carcinoma and its biologic behavior.