Objective To discuss the application value of treating functional dyspepsia with mental intervention.Methods All patients were randomly recruited into a control group and a treatment group. The control group was treated with omeprazole, one granule/time, twice daily; while on this basis, the treatment group was treated with self-made Suganjianpi formula and mental intervention. Results The total effective rate was 90% and 70% in the treatment group and the control group respectively. There was statistical difference between the two groups (χ2=5.69, P＜0.05). Conclusion It was effective to treat functional dyspepsia with mental intervention together with traditional Chinese and western medicines.