Chinese Journal of Clinical Nutrition 2010;18(2):84-86

doi:10.3760/cma.j.issn.1674-635X.2010.02.005

Application of continuous subcutaneous insulin infusion in desensitization for allergy to recombinant human insulin

Naishi LI ; Weigang ZHAO ; Hongbo YANG ; Wenhui LI ; Xiaoling ZOU ; Hui PAN ; Lianglu WANG ; Hongding XIANG

Keywords

Insulin allergy; Insulin analogue; Desensitization; Continuous subcutaneous insulin infusion

Country

China

Language

Chinese

Abstract

Objective To evaluate the values of continuous subcutaneous insulin/rapid insulin analoguc infusion in desensitization for allergy to recombinant human insulin. Methods Two patients allergic to recombinant human insulin received desensitization therapy by continuous subcutaneous insulin lispro infusion. The diluted insulin lispro solution was pumped with initial basal rate of O. O1 U/h, and the basal rate and insulin lispro concentration increased gradually until the insulin dosage for clinical treatment was reached. After that, continuous subcutaneous insulin lispro infusion was replaced by regimen of insulin lispro subcutaneous injection plus oral hypoglycemic agents. Results Local wheals were not observed in both two patients during continuous subcutaneous insulin lispro infusion or during bolus subcutaneous injection of insulin lispro after desensitization. Conclusion The desensitization therapy by continuous subcutaneous insulin/rapid insulin analogue infusion can be applied for allergy to recombinant human insulin.