International Journal of Surgery 2010;37(10):687-690

doi:10.3760/cma.j.issn.1673-4203.2010.10.015

PTEN and thyroid tumor

Fengyan YIN ; Detao YIN

Keywords

Phosphatase and tensin homomlogy deleted on ten; Thyroid cancer; Tumor suppressor

Country

China

Language

Chinese

Abstract

A tumor suppressor gene at 10q23.3, designated PTEN, encoding a dual specificity phosphatase with lipid and protein phosphatase activity, has been shown to play an important role in the pathogenesis of a variety of human cancers and sporadic tumor. In this paper, we reviewed the construction and function of PTEN, and the mechanism of activation in cancer especially in thyroid carcinoma.