Objective To observe the therapeutic effect of Trimetazidine on patients with alcohol cardiomyopathy based on conventional medicine. Methods 46 cases with alcoholic cardiomyopathy were randomly divided into congroup (22 cases) and observation group(24 cases), they were given conventional therapy and additional Trimetazidine for 4 weeks respectively, we estimated therapeutic effect based on 6 min walking experiments, left entricular ejection fraction, and the content of C-reactive protein. Results The results of 6 min walking experiments (543.5 ±69.3) vs (492.7 ± 72.7),left ventricular ejection fraction (44.3 ± 8.6) vs (49.8 ± 9.5) and C-reactive protein content (5.2 ± 0.7) vs (8.9 ± 1.1) in observation group were better than control group. Conclusion Additional Trimetazidine could improve cardiac function by improving cardiacenergy metabolism and anti-inflammatory effect on alcohol cardiomyopathy patients ,Trimetazidine was of great value to generalization.