Objective To analyze and evaluate the application of total parenteral nutrition in our hospital,with an attempt to improve the quality of total parenteral nutrition and provide a reference for clinical use. Method A total of 1386 prescriptions of total parenteral nutrition in our hospital from January 2008 to October 2009 were analyzed and evaluated according to the distribution of the departments and other drug uses. Results All these 1386 total parenteral nutrition prescriptions were mainly made by the departments of gastrointestinal pediatrics, oncology, hepatobiliary gland surgery, and ICU. The average time of use was 7.74 days. More than half of the prescriptions had a liquid volume less than 1500 ml. The volumes of vitamins and trace elements were basically appropriate in most prescriptions. However, problems such as incorrect glucose and lipid energy, low amino acid concentrations, and high Ca2+ or Mg2+ concentrations were also noted. Conclusions The prescriptions of total parenteral nutrition is basically appropriate in our hospital, although there is still space for improvement. More efforts should be made to carry our education and training on nutrition support to promote the reasonal application of total parenteral nutrition.