International Journal of Cerebrovascular Diseases 2010;18(11):865-871

doi:10.3760/cma.j.issn.1673-4165.2010.11.014

Role of nuclear factor-κB in brain ischemic preconditioning

Xin LI ; Guinan BI

Keywords

NF-κB; Brain ischemia; Ischemic preconditioning; Neuroprotective agents

Country

China

Language

Chinese

Abstract

Brain ischemic conditioning (BIP) can improve the tolerance to ischemic injury in the brain. Nuclear factor-κB (NF-κB) is an important transcriptional regulatory factor.It presents in all types of cells in the nerous system. Studies have suggested that BIP may exert neuroprotective effects by mediating NF-κB through a series of cascade reactions. This may provide a new therapeutic strategy for BIP in the prevention and treatment of ischemic cerebrovascular disease in clinical practice.