International Journal of Pediatrics 2011;38(1):47-50

doi:10.3760/cma.j.issn.1673-4408.2011.01.017

Effect of integrin signaling pathway on proliferation and migration of vascular smooth muscle cell

Cuixia LU

Keywords

Integrin; Vascular smooth muscle cell; Proliferation; Migration

Country

China

Language

Chinese

Abstract

Many cardiovascular diseases, such as pulmonary hypertension, atherosclerotic plaque formation and restenosis after angioplasty, are charaterized by vascular remodeling resulting from migration and proliferation of vascular smooth muscle cells. Integin receptors can activate the expression of related genes through the corresponding signal pathway, and lead to vascular smooth muscle cell' s proliferation and migration and other biological behavioral change, which may be a new hotspot of pathogenesis and intervention of vascular remodeling.