Journal of International Oncology 2011;38(2):86-89

doi:10.3760/cma.j.issn.1673-422X.2011.02.002

Association of multidrug resistance gene MDR1 C3435T polymorphism with tumor incidence and treatment outcome

Ziying JIAN ; Baoan CHEN

Keywords

Drug resistance,multiple; Breast neoplasms; Stomach neoplasms; Colorectal neoplasms

Country

China

Language

Chinese

Abstract

Multidrug resistance gene MDR1 C3435T polymorphism influences tumor incidence and treatment outcome. Carcinogenic substances are easier to accumulate in tissue for T allele patients, so TT genotype patients are more likely to develop into breast neoplasms, stomach neoplasms and colorectal neoplasms.Besides, the chemotherapy treatment outcome for patients with both C3435T TT genotype and wild-type KRAS is the best. However, due to ethnic, regional and sample differences, the relationship between C3435T polymorphism and stomach neoplasms 、colorectal neoplasms is still unclear.