Journal of International Oncology 2011;38(2):89-92

doi:10.3760/cma.j.issn.1673-422X.2011.02.003

Advances in research of let-7 in cancer

Xiuming ZHU ; Lingjiao WU ; Fusheng WU

Keywords

MicroRNAs; Neoplasms; Let-7

Country

China

Language

Chinese

Abstract

Let-7 is one of the most widely studied in miRNAs at present. let-7 can inhibit cell proliferation, promote cell differentiation and apoptosis, etc. Reduced expression of let-7 in different human tumor tissues or cells is accompanied by the changes of its target genes expression, which suggests that let-7 is closely linked to cancer.