Journal of International Oncology 2011;38(2):92-96

doi:10.3760/cma.j.issn.1673-422X.2011.02.004

Roles of periostin in cancer

Rong YANG ; Fusheng WU

Keywords

Neoplasms; Angiogenesis inducing agents; Periostin

Country

China

Language

Chinese

Abstract

Periostin, a extracellular matrix protein structurally similar to fasciclin proteins, is expressed specifically in various tumor tissues and correlates with tumor progression and prognosis. Periostin prevents the apoptosis of tumor cells, promotes tumor growth and can induce angiogenic signaling cascades through αvβ3-FAK and Flk-1/KDR. It also contributes to epithelial-mesenchymal-transformation promoting tumor invasion and metastasis. Periostin maybe a potential therapeutic target of cancer treatment.