Journal of International Oncology 2011;38(2):127-129

doi:10.3760/cma.j.issn.1673-422X.2011.02.015

Current research status of TOP2A gene with response to anthracycline-based chemotherapeutic agents in breast cancer

Xuyuan LI ; Weibing LI ; Yingcheng LIN

Keywords

Breast neoplasms; DNA topoisomerases,type Ⅱ; Anthracyclines

Country

China

Language

Chinese

Abstract

Anthracycline-based chemotherapeutic agents were extensively applied to the treatment of breast cancer. The relation of its response to TOP2A gene was proved by a number of clinical studies demonstrating that patients with both HER2 gene amplification and TOP2A gene aberration have a favored outcome,but a consensus was not yet achieved.