International Journal of Surgery 2011;38(1):28-30
doi:10.3760/cma.j.issn.1673-4203.2011.01.009
Advance research of histone deacetylase inhibitors in treatment of prostate cancer
Bo FAN ; Kaili ZHANG ; Enzhong GUO
Keywords
Histone acetylation; Histone deacetylase inhibitors; Prostatic neoplasms
Country
China
Language
Chinese
Abstract
The imbalance between histone acetylation and histone deacetylation can lead to the inactivation of suppressor genes and the activation of oncogenes by influencing transcription. Based on this, researchers found that HDAC inhibitors can induce prostate cancer cells growth arrest, differentiation and apoptosis. This review summarizes the advance research of histone deacetylase inhibitors in treatment of prostate cancer.
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