Clinical Medicine of China 2011;27(1):80-82

doi:10.3760/cma.j.issn.1008-6315.2011.01.026

Clinical effect of adult stem cell application in motor neuron disease in 20 cases

Liming WANG ; Jianjun ZHOU ; Wen BAI ; Bin BAI ; Jianjun LI ; Lihua WANG ; Yongjun LIU

Keywords

Motor neuron disease; Adult stem cell; Autologous Hematopoietic stem cell

Country

China

Language

Chinese

Abstract

Objective To study the feasibility of adult stem cell therapy in motor neuron disease. Methods From May 2008 to March 2010, twenty patients with motor neuron disease were treated with adult stem cell. The patients were divided into two groups with umbilical cord mesenchymal stem cell in 14 cases (group A)and autologous Hematopoietic stem cell in 6 cases( group B). 4 ml stem cell ( ＞ 1.0 × 107) were given through subarachnoid injection. 1.0 × 107 cell were injected each time, and rehabilitation were performed simultaneously. Results Seven patients have improved in the dysphagia, bucking, continuity of language and thinking and reaction after 2 weeks' treatment. Seven patients improved remarkably in myodynamia( from Ⅲ to Ⅳ ). There was no effect observed in 6 patients. Three patients died during the follow up for 3 - 6 months. Three patients were followed up for 18 to 24 months and their condition did not getting worse. Conclusion Adult stem cell transplantation may be a safe and practical new ways to treat motor neuron disease.