International Journal of Pediatrics 2011;38(1):18-21

doi:10.3760/cma.j.issn.1673-4408.2011.01.007

Progress in pathogenic secretome research

Shuxian LI ; Dan XU

Keywords

Secreted protein; Secretome; Pathogen; Proteomics

Country

China

Language

Chinese

Abstract

Secretome includes all the gene products secreted by a cell. The development of proteomicbased approaches and genome-based computational prediction technology have gradually revealed secretome plays an important role in pathogen infection recently. Secretome facilitates pathogen to proliferate and invade the host by inhibiting the host's immune system, resisting acidic PH conditions, snatching nutrition and so on.Identification of pathogenic secretome helps discovering new drug targets and biomarkers, and supporting the diagnosis and treatment.