Objective To evaluate the clinical efficacy and safety of praeparatum containing glycerin and sesame oil in treating dry skin patients. Methods one of patient's limbs was randomly selected to use praeparatum containing 23. 8 % glycerin twice a day, and the other side to use praeparatum containing 43. 7% sesame oil twice a day. During 14 days, the effects were observed and recorded when following-up at the days 0,3,7 and 14. Extent of drying was measured by evaluating each of the clinical symptoms (rough, drying and scale) and the following parameters were also evaluated: stratum corneum hydration (SCH) and trans-epidermal water loss (TEWL). Results The clinical trial was completed in 24 xerosis patients, including 10 males and 14 females. The clinical scores for rough, drying and scale, were assessed by the patients and doctors, and both experimental and control groups were improved. Stratum corneum hydration was improved, trans-epidermal water loss was reduced, and both values had statistically significant difference (P<0. 01). There were no adverse reactions in all the patients during this experiment. Conclusions Both praeparatum containing glycerin and sesame oil could improve the condition of skin safely and effectively in xerosis patients, and the efficacy of glycerin praeparatum is better than sesame oil praeparatum.