Japanese Journal of Cardiovascular Surgery  2013;42(2):124-127

doi:10.4326/jjcvs.42.124

Collagen Gel Droplet-Embedded Culture Drug Sensitivity Test (CD-DST) for a Leiomyosarcoma Originating in the Inferior Vena Cava

Nobuo Kondo ; Masaki Yamamoto ; Hideaki Nishimori ; Takashi Fukutomi ; Seiichiro Wariishi ; Kazuki Kihara ; Miwa Tashiro ; Kazumasa Orihashi

Keywords

leiomyosarcoma in the inferior Vena cava; CD-DST; reconstruction of inferior Vena cava; anticancer drug sensitive test

Country

Japan

Language

Japanese

Abstract

The collagen gel droplet-embedded culture drug sensitivity test (CD-DST) identifies effective anticancer drug using resected tumor specimen, enabling tailor-made chemotherapy for a rare tumor. We report a case of the patient with leiomyosarcoma originating in the inferior vena cava, to which CD-DST was applied. This application has not been previously reported to the best of our knowledge. A 61-year-old woman consulted a nearby hospital because of abdominal pain. Computed tomography revealed an inferior vena cava tumor. The tumor was resected with the inferior vena cava, which was reconstructed with a 16 mm ePTFE graft. The tumor was diagnosed as leiomyosarcoma histopathologically. CDDP, VP-16, ADR, and VDS were CD-DST showed the tumor to be sensitive. Her postoperative course has been good without recurrence of tumor for 6 months, and the results of CD-DST may be helpful for chemotherapy strategy in case of recurrence.